What is NIPT?
NIPT (Non-Invasive Prenatal Testing) analyses cell-free DNA fragments circulating in the mother's bloodstream. From a maternal blood sample, the laboratory estimates the chance of selected chromosomal conditions. It is non-invasive to the pregnancy, but it remains a screening test and does not assess every genetic condition.
When can NIPT be done?
Any time from 10 weeks 0 days onwards. Results in 7–10 days. Testing early leaves ample time for confirmatory diagnosis if ever needed.
What Does NIPT Screen For?
- Trisomy 21 (Down syndrome) — high-sensitivity screening; performance varies by laboratory and patient factors
- Trisomy 18 (Edwards syndrome) — screening performance differs from Trisomy 21 and depends on the laboratory panel
- Trisomy 13 (Patau syndrome) — screening performance differs from Trisomy 21 and depends on the laboratory panel
- Sex chromosome conditions (Turner, Klinefelter) — extended panels
- Selected microdeletion syndromes — where clinically indicated
Why do NIPT at a dedicated fetal medicine center?
NIPT is only as good as the counselling around it. A high-risk result without expert guidance causes needless panic; a low-risk result without a proper scan gives false reassurance. At Dr. Mathew's center in Kollam you get pre-test counselling, the right panel selection, correct interpretation, and — if ever needed — confirmatory amniocentesis under one roof. This is the standard of care followed in international fetal medicine practice.
NIPT and the NT Scan — Better Together
NIPT reads DNA; it cannot see anatomy. The 11–14 week NT scan detects structural problems, confirms your dates, diagnoses twins, and identifies early markers that NIPT cannot. International guidelines — including FMF UK protocols — recommend combining NIPT with the first trimester scan for the most complete early assessment of your baby.
What to Expect
A brief counselling session with Dr. Mathew is followed by a maternal blood draw; fasting is not required. Because no needle is placed into the uterus, NIPT does not carry the procedure-related miscarriage risk of CVS or amniocentesis, although ordinary blood-draw discomfort or bruising can occur. The accredited genetics laboratory processes the sample, and Dr. Mathew explains the report and any next step.
Serving South Kerala: Families travel for NIPT counselling and testing from Kollam, Kottarakkara, Karunagappally, Kundara, Paravur, Punalur, Kayamkulam, Pathanamthitta, Alappuzha, and Thiruvananthapuram — because a blood test with expert fetal medicine counselling is worth the journey.